ChEM-H Room N327
nsgray01@stanford.edu

Probe Resources

Probe Resources

The Gray lab believes in an open-source drug discovery model and we attempt to make all of our published compounds available to the research community. Making the probe compounds generally available greatly diversifies and amplifies the discoveries that are made. Probes can be searched by category (degrader or inhibitor) and/or targets. The data sheet lists all the relevant information about the probe including commercial availability and vendor information. The profiling data sheet lists DiscoverX KINOMEscan kinase profiling data and presents the data graphically on TREEspot Kinase Dendrograms.

ALV-04-019-01

Target: IKZF2/4

Reference:
Nat Chem Biol. 2021 Jun;17(6):711-717.

ALW-II-49-7

Target: DDR2

Reference:
ACS Chem. Biol., 2015, 10 (12), pp 2687–2696

Aurora-compound 1

Target: Aurora

Reference:
ACS Chem. Biol. 2012, 7, 1, 185–196

BJG-03-025

Target: FAK

Reference:
ACS Med Chem Lett. 2020 Dec 14;12(1):30-38.

BJP-06-005-3

Target: PIN1

Reference:
Nat Chem Biol. 2020, 16(9), 979-987

BMX-IN-1

Target: BMX, BTK

Reference:
ACS Chem. Biol. 2013, 8, 7, 1423–1428

BSJ-03-123

Target: CDK6

Reference:
Angew. Chem. Int. Edit., 2019, 58, 6321-6326.

BSJ-03-204

Target: CDK4, CDK6

Reference:
Angew. Chem. Int. Edit., 2019, 58, 6321-6326.

BSJ-04-122

Target: MKK4/7

Reference:
Cell Chem Biol. 2020 Dec 17;27(12):1553-1560.e8

BSJ-04-132

Target: CDK4

Reference:
Angew. Chem. Int. Edit., 2019, 58, 6321-6326.

BSJ-4-116

Target: CDK12

Reference:
Nat Chem Biol. 2021 Jun;17(6):675-683.

CVM-6-139-1

Target: HIPK2

Reference:
Neuron. 2016, 91(1), 41-55.

dBET6

Target: BRD4

Reference:
Molecular Cell, 2017, 67(1), 5-18.e19.

dBRD9

Target: BRD9

Reference:
Angewandte Chemie 2017, 56(21), 5738-5743

dBRD9-A

Target: BRD9

Reference:
eLife 2018;7:e41305.

DCLK1-IN-1

Target: DCLK1

Reference:
Nat Chem Biol. 2020 Jun;16(6):635-643.

DD-03-171

Target: BTK

Reference:
Blood. 133(9):952-961 (2019)

DDC-01-163

Target: EGFR

Reference:
Angewandte Chemie Int. Ed. 2020, 59, 14481-4489

DDC-03-024-01

Target: EGFR

Reference:
ACS Med. Chem. Lett. 2019,10, 1549-1553

DDR1-IN-1

Target: DDR1

Reference:
ACS Chem. Biol. 2013, 8, 10, 2145–2150

DGY-06-116

Target: SRC

Reference:
J. Med. Chem. 2020, 63, 4, 1624–1641

DGY-08-097

Target: HCV Protease NS3/4a

Reference:
Nat Commun. 2019 08 01; 10(1):3468.

HCV Protease NS3/4a

DGY-09-192

Target: FGFR

Reference:
Angew Chem Int Ed Engl. 2021 Jul 12;60(29):15905-15911.

dTAG-13

Target: FKBP12F36V

Reference:
Nature, 2017, 543, 270–274

dTAGv-1

Target: FKBP12F36V

Reference:
Nat Commun, 2020, 11(1), 4687.

dTRIM24

Target: TRIM24

Reference:
Nat Chem Biol. 2018, 14(4), 405-412

FIIN-1

Target: FGFR

Reference:
Chemistry & Biology 2010, 17(3), 285-95

FIIN-2

Target: FGFR

Reference:
PNAS November 11, 2014, 111 (45) E4869-E4877

FIIN-3

Target: EGFR, FGFR

Reference:
PNAS November 11, 2014, 111 (45) E4869-E4877

FMF-01-086-2

Target: Aurora

Reference:
Bioorg Med Chem Lett. 2017, 27(18), 4405-4408

FMF-02-063-1

Target: PI3K

Reference:
ACS Med Chem Lett. 2016 Aug 2;7(10):908-912

FMF-03-145-1

Target: Aurora

Reference:
Bioorg Med Chem Lett. 2017, 27(18), 4405-4408

FMF-04-159-2

Target: CDK14

Reference:
Cell Chem Biol. 2019, 26(6), 804-817.e12.

FRF-01-116

Target: KRAS G12C

Reference:
Cell Chem Biol. 2017; 24 (8): 1005-1016

GNF-5

Target: Bcr-Abl, c-Abl, c-Arg

Reference:
Nature. 2010, 463, 501-507.

Bcr-Abl, c-Abl, c-Arg

HG-10-102-01

Target: LRRK2, MLK1, MNK2

Reference:
ACS Med Chem Lett. 2012 Aug 9;3(8):658-662

LRRK2, MLK1, MNK2

HG-7-85-01

Target: Bcr-Abl, cKit, PDGFR, Src+gatekeeper mutants

Reference:
Blood, 2010, 115(21), 4206-4216,

Bcr-Abl, cKit, PDGFR, Src+gatekeeper mutants

HTH-02-006

Target: NUAK2

Reference:
Nat Commun. 2018, 9(1), 4834.

INY-03-041

Target: AKT

Reference:
Cell Chem Biol. 2020, 27(1), 66-73.e7

JBJ-04-125-02

Target: EGFR

Reference:
Cancer Discov. 2019, 9, 926-943

JH-II-127

Target: LRRK2

Reference:
ACS Med. Chem. Lett. 2016, 6, 584-589

JH-IX-179

Target: FLT3

Reference:
ACS Med. Chem. Lett. 2016, 7 (5), 476-481

JH-X-119-01

Target: IRAK1

Reference:
ACS Med Chem Lett. 2020 Oct 9;11(11):2238-2243.

JH-XI-05-01

Target: SRPK

Reference:
Cell Chemical Biology 2018, 25(4), 460-470.e6.

JH-XI-10-02

Target: CDK8

Reference:
ACS Med. Chem. Lett., 2018, 9 (6), 540–545.

JNK-IN-8

Target: JNK

Reference:
Chemistry & Biology 2012, 19(1):140-154

JWG-071

Target: ERK5

Reference:
ACS Chem Biol, 2018, 13(9), 2438-2448.

LRRK2-IN-1

Target: ERK5, LRRK2

Reference:
Nat. Chem. Biol. 2011, 7, 203-205.

MFH290

Target: CDK12, CDK13

Reference:
J. Med. Chem. 2020, 63, 13, 6708–6726.

MPS1-IN-1

Target: MPS1

Reference:
Nat. Chem. Biol. 2010, 6(5), 359-68.

MPS1-IN-2

Target: MPS1

Reference:
Nat. Chem. Biol. 2010, 6(5), 359-68.

MYF-01-037

Target: TEAD

Reference:
Cancer Cell 37, 104-122.e112.

NG25

Target: MAP4K2, TAK1

Reference:
J. Med. Chem. 2015, 58, 1, 183–196

Pin1-3

Target: PIN

Reference:
Nat Chem Biol. 2021 Sep;17(9):954-963.

QC-01-175

Target: Tau

Reference:
Elife, 2019, 8:e45457

SCM-02-138

Target: MALT1

Reference:
J Clin Invest. 2018, 128, 4397.

SYN-DFCI-00114

Target: TNK2

Reference:
Bioorg Med Chem Lett 30(19): 127456

TAF1-compound 31

Target: TAF1

Reference:
ACS Med Chem Lett 2019, 10(10), 1443-1449

THAL-SNS-032

Target: CDK9, CDK10

Reference:
Nature Chem Biol, 2018, 14, 163-173

THZ-P1-2

Target: PI5P4K

Reference:
Cell Chem. Bio. 2020, 27, 525–537

THZ1

Target: CDK7

Reference:
Nature, 2014, 511, 616–620

THZ531

Target: CDK12, CDK13

Reference:
Nat Chem Biol. 2016; 12(10): 876–884

TL13-112

Target: ALK

Reference:
J. Med. Chem. 2018, 61, 9, 4249-4255

TL4-12

Target: MAP4K2

Reference:
J. Med. Chem. 2015, 58, 1, 183–196

TL6-144

Target: JAK3

Reference:
J. Med. Chem., 2015, 58 (16), pp 6589–6606

TM-04-176-01

Target: PI5P4K

Reference:
J. Med. Chem. 2020, 63, 4880−4895

TMX-2164

Target: BCL6

Reference:
ACS Med. Chem. Lett. 2020, 11, 1269-1273

TMX-2172

Target: CDK2

Reference:
Angew. Chem. Int. Ed., 2020, 59, 13865-13870

Torin1

Target: mTOR

Reference:
J Med Chem. 2010, 53(19), 7146-55.

Torin2

Target: ATM, ATR, DNA-PK, mTOR

Reference:
J Med Chem. 2011, 54(5):1473-80

ATM, ATR, DNA-PK, mTOR

WZ4002

Target: EGFR

Reference:
Nature 2009, 462, 1070-4

XMD8-87

Target: TNK2

Reference:
Cancer Res. 2016, 76(1), 127-38.

XMD8-92

Target: ERK5

Reference:
Cancer Cell, 2010, 18, 258-267.

XY-02-082

Target: KRAS G12C

Reference:
ACS Med. Chem. Lett., 2017, 8, 61–66.

YKL-01-116

Target: CDK7

Reference:
Cell reports 21.2 (2017): 467-481.

YKL-05-099

Target: SIK

Reference:
ACS Chem. Biol., 2016, 11 (8), pp 2105–2111.

YKL-05-124

Target: CDK7

Reference:
Cell Chem Biol. 2019, 26(6), 792-803.e10.

YKL-06-061

Target: SIK

Reference:
Cell Rep. 2017, 19, 2177-2184.

ZNL-02-096

Target: WEE1

Reference:
Cell Chem Biol. 2020, 27(1), 57-65.e9.

Quick Reference

Degraders

CDK4, CDK6
CDK4
BRD4
BRD9
BRD9
BTK
EGFR
HCV Protease NS3/4a
FKBP12F36V
TRIM24
AKT
CDK8
Tau
CDK9, CDK10
ALK
CDK2
WEE1
FKBP12F36V
CDK6
CDK12
FGFR
IKZF2/4

Inhibitors